Cellulose derivatives such as (hydroxypropyl)methyl cellulose (HPMC) and methyl cellulose (MC) are temperature-sensitive materials used in the synthesis of hydrogels. Hydrogen bonding between polymer and water became weaker at the LCST than polymer–polymer and water–water interactions.
Cellulose ethers and cellulose esters are the two most common types of cellulose derivatives, each with its own set of mechanical and physicochemical properties. These polymers are mostly found in healthcare products and dosage form formulation.
Cellulose derivative have high lubricity, thickening, water retention, binding, and film formation properties. As a result, consumption of cellulose derivatives has increased in the mining, construction paper, and personal care industries.
Hydroxypropylmethylcellulose is the most commonly used mixed ether cellulose derivative in the pharmaceutical industry (HPMC). It is a nonionic polymer that is water soluble and has a molecular weight ranging from 10,000 to 150,000. It is made by derivatizing 16.5 percent–30% of the hydroxyl groups with methyl groups and 4 percent–32 percent with hydroxypropyl groups.
Cellulose derivative have been used to functionalize the surface properties of nanocellulose due to their natural affinity for it. There have been several methods reported for surface grafting nanocellulose with carboxymethyl cellulose, but the negative charge of carboxymethyl cellulose is detrimental to high nanocellulose adsorption. Unmodified hemicellulose derivatives, on the other hand, such as xyloglucans, arabinoxylans, and O-acetyl galactoglucomannan, can be grafted to the surface of nanocellulose in significant amounts, making them promising grafting starting materials.
The increasing use of cellulose derivatives in pharmaceutical manufacturing to meet the demand for advanced drugs such as acyclovir, as well as its growing use in the personal care industry, is a major factor driving the growth of the cellulose derivative market. The Asia Pacific region is expected to be the most promising market for cellulose derivatives manufacturers. This is primarily due to the region's robust growth in major end-use industries such as automotive, pharmaceuticals, and personal care products.
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