The term "neuromodulation" refers to "the modification of nerve activity through the targeted delivery of a stimulus, such as electrical stimulation or chemical agents, to specific neurological sites in the body." It is done to normalise – or modulate – the function of nervous tissue. Neuromodulation is a developing therapy that can include a variety of electromagnetic stimuli such as a magnetic field (rTMS), an electric current, or a drug injected directly into the subdural space (intrathecal drug delivery). Emerging applications include the targeted introduction of genes or gene regulators as well as light (optogenetics), and by 2014, these had been at least demonstrated in mammalian models or first-in-human data had been obtained. Electrical stimulation has provided the most clinical experience.
According To Coherent Market Insights " The global neuromodulation devices market is estimated to account for US$ 9,298.7 Mn in terms of value in 2020 and is expected to reach US$ 24,768.8 Mn by the end of 2027. "
Neuromodulation devices are appealing options for migraine sufferers. It's difficult to predict which patients will respond best to the devices, but it's a viable option for those who have health issues or conditions that prevent them from taking medications, or who have medication tolerability issues, or who are concerned about medication overuse headache.
Neuromodulatory treatments, as well as the associated investigational work, frequently necessitate multidisciplinary teams. This means that a variety of professionals with varying levels of expertise collaborate with the common goal of improving clinical management. As a result, research in related fields has flourished in tandem with the increase in the number of clinical indications and studies using neuromodulation therapies.
Neuromodulation, which is elicited by electrical stimulation of peripheral or spinal nerves, is a therapy approved by the US Food and Drug Administration for treating a variety of pelvic visceral disorders. Although the precise mechanisms underlying neuromodulation's effects are still unknown, it is widely assumed that its beneficial effects are due to the activation of somatic afferent nerves, which causes the release of neurotransmitters in the central nervous system, resulting in the modulation of abnormal visceral sensory and motor mechanisms.
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